The collection of dead skin cells in the cracks of mice due to advanced levels of gaming.
Dude, your mouse is full of nerd grime.
by DaveIsANerd January 19, 2012
1 more definition
The grime that collects on gaming mice and mechanical keyboards after countless hours of being handled by nerds.
I have to clean that nerd grime off my mouse before I go to the LAN.
by zedd11 January 09, 2012