Top Definition
Coined by half of the popular radio duo "Opie and Anthony," Greg "Opie" Hughes considers Myspace voodoo the art of a large or unattractive woman disguising herself with clever camera tricks in order to appear seductive, skinnier, or more aesthetically appealing in some way.
I met that girl the other day, but let me tell you, that was some serious Myspace Voodoo going on.
by thefirebuilds December 09, 2007

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