1. Modus Operandi (method of operation), how you do something

2. Multiple Orgasm
1. The killers MO was drowning his victims

2. "I gave Krista the best sex of her life last night. She totally Mo'd."
by Changsta December 19, 2005
a gang stone they say allzwell mo run under da 5 point star hate gd'z they call dem bricks
whut up mo
by lil mo December 10, 2003
Homosexual -- Short for homo

Generally, derogatory
Dude... Paul is such a 'mo.
by Jeff December 27, 2002
When used in north eastern New Jersey/New York "Mo" generally stands for "Moron".
"My dad is such a mo. He got arrested for assaulting an officer again."
by LK865 November 18, 2011
Method of Operation
Tianna's M.O. is always go in, be an annoying little bitch, walk out, and watch everyone hate her.
by MyMotherCanRotInHell March 11, 2010
Mo is another way of saying no, just cuter and better.
"Mo!" said Sally the five-year-old "I won't cwean my woom!"

"Mo way! You are way cuwter than my ex!" said John to Tasha in his cutesy girlfriend voice.
by smahteepants July 20, 2009
When someone is taught something and deliberately does it there own way in spite. This often leads to disaster.
Don't pull a Mo dude.
by Shydog August 23, 2008

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