Meth'd-Up is a play on Messed-Up. Used in a loving way to poke fun at a meth addict who is messing up or who demonstrates messed-up behavior.
Boy that Carrie sure is Meth'd-Up!

Where's My Precious? It's time to get Meth'd-Up!
by Carrie's Carrying January 8, 2021
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Seen when someone is completely restless beyond the help of any person, or depressant drug. Common effects are a person talking faster than words come out of their mouth, fast leg shaking, finger twitching, and looking around, all at very fast speeds. This usually happens when a person takes more than one amphetamine dose, especially when they don't have adhd.
Kyle got on the bus and the kid behind him, who was Meth'd out jumped over a bus seat and walked 4 times as fast as kyle down the bus isle, frantically looking for a seat.
by idontusedrugz October 9, 2010
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