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1. Mesembrine is an alkaloid present in Sceletium tortuosum.

2. It has been shown to be an extremely potent serotonin reuptake inhibitor, active at dosages as low as 100μg (micrograms).

3. It has also been shown to be a PDE4-inhibitor.3 Mesembrine may contribute to the antidepressant effects of kanna.
Wow, this kanna sure does seem like it is loaded with Mesembrine!
by Nicholas Roberts March 31, 2008