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1.
cheap shot, sucker punch, having no class, dirty, an unnecessarily aggressive and unfair attack directed at a defenseless person
dang homie, you just got "mayweathered"
by lile broadway September 17, 2011
 
2.
When things happen without being prepared for it; not looking; not paying attention; didn't see it coming.
Always keep an eye, you don't wanna get mayweathered just like Ortiz!
by Kobe2010 September 18, 2011