The act or process of going crazy, usually caused by life stressors. Also used in the past tense phrase: lost my marbles. The orgin of the phrase is unknown but has been referenced numerous times in popular culuture; such as in the peter pan film Hook from the 90’s.
I am losing my marbles staying locked up in this jail cell.

Jimmy spent his entire summer indoors studying and ended up failing his medical boards, he has since then lost his marbles and is living under a bridge.
by yabayabadoo August 12, 2011
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Being in the the state of confusion and absolutely going bonkers. The person who says this phrase usually states it in a tone where they are rather stern and will get ready to square up on the spot (known from experience).
Shannon- Sweetie, are you alright? You're strangling the dog again!

Bertha- I'm about to lose my marbles!
by Anti-Vaxx Parent May 11, 2019
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