Top Definition
The tendency for the lead singer of a rock band to become egotistical and impossible to work.

There are a number of factors that can contribute to the onset of LSD including; a natural tendency in the singer to act like a prima donna and treat other people like shit, the level of fame and fortune the band manages to achieve (whether deserved or not), how quickly the band goes from being dirt poor and unknown to filthy rich and overly famous, and whether or not other members of the band have enough talent to compete with the singer for the public and the media's attention.

LSD is often fatal… …for the band. Once a singer develops LSD there is very little hope of them ever recovering from it.

PLAIN ENGLISH VERSION: Lead singer's disease is what happens when a lead singer lets the success of their band go to their head, starts acting like he or she is god and begins to demand that everything be done their way. If they don't get their way their inflated ego makes them think that they don't need the other band members and the band splits up.
Who do you think is a worse case of lead singer's disease, Axl Rose or David Lee Roth?
by amoebabadass August 12, 2007

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