Top Definition
a "pandemic" that is used by boys as an exuse to hold a girl's hand. Very effective. The only known cure is to hold the girls hand and apply pressure. You must also give the girl a hug after letting go of her hand.
Linus: OMG!!!
Taylor: What?
Linus: You have Knuckleitis!
Taylor: oh no!
Linus: Ill save you! now give me your hand.
by Trevor3657 February 11, 2009
11 Words related to knuckleitis

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