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1.
herion
knucklebump all up in this whoa!
by faggymcfaggerton November 23, 2010
 
2.
To snort a small amount of cocaine from the creases of your knuckle. Usually the most discreet way to snort in public (club, party, street) so that no one will suspect anything.
Ben: Did you see that chick knuckle bump?

Tice: I sure did.
by Nick Bowling Green April 25, 2006