The acronym for it's Still Yo Mother Fuckin' Set.

A term used bodybuilders and weightlifters alike indicating you have not completed a repetition for a particular workout.
Guy 1: My girl just called. I gotta be outta here.

Guy 2: You cannot leave just yet. ISYMFS
by jasonthecancer March 10, 2014
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The acronym for I Suck Your Mother's Fingers Slowly.

Term used by MILF lovers and feet fetishists. Often tattooed on different body parts to inform cougars about your preferences.
Woman: Hey is that ISYMFS on Your arm?
Boy: Yes it is.
Woman: Let's go to my house and talk about it.
by MichealQA August 13, 2019
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