Top definition
A woman who is extremely difficult to tolerate for any reasonable length of time. This normally due to a personality defect, or a disorder of the mind. Often these unfortunates are medicated with psychotropic drugs.
1. That woman became an insufferable bitch when she didn't take her medication.

2. One wonders what happened to her that made her such an insufferable bitch.
by Rook's Buddy May 11, 2010
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