Top Definition
this stands for..... "i'm such a f**king retarded idiotic loser! it is pronounced eye-is-a-frill.
also i.s.f.r - i'm so f**king retarded.
emily: aghhh!!
jake: sup??
emily: i.s.a.f.r.i.l......i've done it all wrong ill have to start over!!!
by Tango_Whore November 27, 2005
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