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1.
TO get over excited and to start things you do not mean to start. It's a form of getting out of control. Over stepping a boundary.
"yo don't hype up szeen"
"your girl shyniqua is hypin' up, still."
"slow your roll, quit hypin' up".
"relax, no need to hype up on no one"
by Shex May 02, 2006
 
2.
Get high of of a mix of Adderall and Oxycodon
"Dude i got such a hype-up off that crushed up oxy and adderall when i snorted it"
by Johnny Ravencall April 10, 2008