Top Definition
Southern expression: To refrain from beating some one's ass.
Origin: Has something to do with Jesus and his mule.
Son: Mommy, my teacher called me a dummy.
Mom: Lawd! Somebody hold my mule!

Tom: I heard that you got fired.
Dan: Yeah, I had to hold my mule on them beeotches!

Trina: Girl! They repossessed my car!
Keshia: Hold my mule!!!
by CatSuga October 10, 2006
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