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1. any potent liquor

2. a powerful and potentially dangerous drug
Lay off the hard stuff. Quit while you are ahead.
by The Return of Light Joker March 26, 2009
An alcoholic beverage that contains a high percentage of alcohol and/or will intoxicate someone very quickly. 100 proof.
Just give me some of the hard stuff.
by Kevino June 16, 2006