Top definition
A person who is causing you trouble or bother, especially in an odd, reality-disrupting way, is glitching your matrix.

It can also be used as a curse/cry for help to an unseen, unresponsive deity for people undergoing philipkdickian existential crises.
"Fuck off, you're glitching my matrix." or "Stop glitching my matrix, God."
by Charles Hoffmann August 27, 2010
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