Allowing someone to enter you by submission or by force through the anal cavity.
yo homie you gonna have to let me get some of that, you gonna have to give up dem cheeks.

Eh girl you looking kinda good you wanna give up den cheeks.
by Givin up dem cheeks!!! May 18, 2015
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"I hid in the closet and watched Janet giving up some neck to Randy. It was like Linda Lovelace on Ron Jeremy."
by keifermail July 12, 2009
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Replace those give-up-on-life pants with take-over-the-world pants & do something BIG!
by Johnny sons October 7, 2023
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to cheer for someone, or what they bring to the game
Give it up to your dj on the 1-2s keepin it crunk for the party
by DJ Kayla March 1, 2004
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to give in to one's sexual urges in a quick manner; usually referring to females
dang i was with abby for 10 mintes when she was ready to give it up!
by the give it upper March 3, 2004
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The act of an individual allowing his/her partner to make an insertion into their asshole.
She likes giving up the dookie.
by she gives me the dookie May 18, 2010
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