Top Definition
What happens to your thumb after playing 2 or more consecutive hours of video games, especially games where you have to continuously tap buttons to get up and/or use the analog sticks.A blistered, red sensitive thumb. See nintendo thumb and playstation thumb.
If you play a Def Jam game, game thumb is a given. Bet on it.
by Nastina September 07, 2005
2 Words related to game thumb
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