Top Definition
An amusing slang term for any of a number of venereal diseases. While the word is most commonly used in reference to gonorrhea and chlamydia, it can describe any STD other than HIV/AIDS. Also known as knob rot and crotch rot. Extreme cases may be classified as Rampant Galloping Cock Rot.
What the fuck? I bang a couple of hoes, and now I've got the galloping knob rot!
by Blackwolf Morrow July 25, 2005

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fraying of the banjo from excessive use of the mouse's ear
i was on the case last night, banged her so many times i woke up with the worst case of galloping knobrot
by cunning linguist October 20, 2003

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