When a simple 'fuck you' will not suffice. Used in extreme cases. Note: Use with care. An over-use of this word causes a severe decrease in its value and over all special-ness.
Tina's fiance just told her that he is leaving her for her maid of honor, Janis, will be going on their honey moon with Janis, will NOT provide child-support for his and Tina's unborn son, and that Tina looks fat in her wedding dress.
"Well, fuck the hell outta you, motherfucker!"