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Somebody who is incredibly lazy, always late, doesn't like to move, or is just slow in general.

it originates from the animals, the two-toed and three-toed sloths.
"'shit dude, Jed said he'd be here three hours ago, do you think he's ok?'

'man, he's fine, he's always late; he's like a fuckin' five toed sloth or something'"
by fivetoedsloth October 05, 2009
Someone who is exceptional slow. Especially when running or in hand-eye coordination.
"Jack's a good athelete."
"Yeah, he's coordinated, but he's so slow he looks like a five toed sloth."
by Legbah February 04, 2008