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1.
Out of order; unusual behaviour; operational but not quite to full capacity.

A person who is out-of-sync with their regular routine.

Machine or equipment that is not working properly or is uncalibrated.
Ex. 1
Person 1: "Whats the matter? Is something bothering you?"
Person 2: "No, but something has me dysregulated."
Ex. 2
"I wouldn't trust the reading on that scale, it's been dysregulated since Fat Mike came to visit."
by DD&EB January 25, 2013