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15.
Short for Down-syndrome. The term is commonly used to label bronies, or also known has the mentally ill people who watch the show My Little Pony or to what they refer to as, MLP. The term is also commonly used on really stupid people on the internet that try to troll.
Anti Brony: Ewww look a brony! Stay away he has downs.
Normal Person: Now that I think of it...bronies do have downs! Ahhhhh! Run!
by Trjx March 30, 2014
 
16.
when someone smokes weed and acts like they have down syndrome.
mostly a code word for are you high
Nikko: yo do you have the Downs right now?
Billy: nah dude, im good.... nottttttt!!

Sam:wow that nigga got the Downs right now.

DOWNSSSSS
by bktherealking November 13, 2011
 
17.
A person with a repulsive personality. In social situations, one would want to run from this individual. They thrive on their own awkwardness, and demonstrate physical and mental abilities of one with down's syndrome.
Jimmy: "Ugh, she won't hop off the tip."
Doug: "Are you talking about Downs again?"
by Manny101 October 11, 2011
 
18.
Down's syndrome for people just seem like they have downs syndrome. Symptoms include but are not limited too: Saying things that make no sense at all, sexing inanimate objects, thinking questions are multiple choice when they aren't, and overall just being fucking retarded. Have a mating call resembling that of the cookie.
Feivou: Dude lets draw Koreans suicide bombers!
Bates: No you fucktard gay boy. I think you have downs.
Thomas:Mehhhhehehhhehehhh!!!?!?!!
by Jew by four March 24, 2011
 
19.
A person, usually a gangsta or cholo, who will do anything for his/her homies, crew, hood, or family.
"that fool's down as fuck, he'll take anyone."
by mateothathug September 07, 2007
 
20.
Down is used in a few ways in New Orleans. 1. Down to be willing to help, keeping something real, bout whatever u bout. 2. Down as oral sexual positions used by males and females . 3. Down as get the F... , go head, yeah right and used when upset or denying something. 4. Down as wilding out, having fun, a good time, something exciting, fighting, arguing. *Also, used to describe hurting someone's feeling, being sad, depressed, guilty.
1. My boy is down for me. Are you down for a drink? Girl, I didn't know get down like that.
2. He went down on me last night.
3. Boy Down, you don't me like that. Girl Down,I hear ya.
4. It went down in Club Xscape, Saturday. Girl you missed it, it was about to go down at work today.
5. I feel down and out. I wish he would say something cause I'm gone down his ass.
by Putty the pimp June 15, 2006
 
21.
a pimp's pressure on a whore, or his adherence to the rules of the pimp game; when a whore starts to work.

source from Iceberg Slim, Pimp: The Story of My Life
Playa, you gotta keep this bitches down, less they betray you.
by bobo32 April 27, 2010