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A discombobulated melancholy is a long-lasting depression.

Melancholy is usually used as an adjective, but it becomes a noun when combined with the word discombobulated. It's often associated with emos.
 
Adult: "I don't get it, why can't you just hang out with other kids, have fun?"

Emo kid: "I'm suffering from a discombobulated melancholy. Just leave me alone."
by St.Louis April 22, 2010
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