deep cotton 

Equivalent to deep shit. Deep doo-doo. You get the gist of it.

If you keep shooting your mouth off to the cops, you're gonna be in deep cotton.

deep cotton by Bagboy's Papa November 3, 2013

Deep South Cotton Mouth 

Refers to an extreme thirst brought about while high on marijuana.

Symptoms include: Extremely dry mouth, Excessive thirst, and a motivation to drink everything in sight.

Also referred to as simply, deep south

James Bonfire had Deep South Cotton Mouth last night and drank 5 water bottles in an hour

Deep South Cotton Mouth by James Bonfire June 24, 2011