Equivalent to deep shit. Deep doo-doo. You get the gist of it.
If you keep shooting your mouth off to the cops, you're gonna be in deep cotton.
by Bagboy's Papa November 4, 2013
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Refers to an extreme thirst brought about while high on marijuana.

Symptoms include: Extremely dry mouth, Excessive thirst, and a motivation to drink everything in sight.

Also referred to as simply, deep south
James Bonfire had Deep South Cotton Mouth last night and drank 5 water bottles in an hour
by James Bonfire June 24, 2011
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