Its when something doesnt go as planned or when your plans and or relationships or friendships get fucked off due to sex drugs or money. Sex drugs and money being the "game" and because people do things they wouldn't normally do when these things are involved.
Rocco took garys car from him last night. I heard it was because gary gave roccos girlfriend ecstacy and tried to fuck her. He better chalk it up to the game.Hes never gonna get that car back.
When something occurs you have no control over and nothing/no one has direct responsibility for. Essentially there is no use fighting the situation because nothing is going to change it. Throw in the towel, give up
Man, nothing seems to be working out, might as well chalk it up to the game.