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1.
big tits. Derived from the F-cup chick Bernadette, nicknamed Detticles. Somehow this name was changed to Callisters, which now means big tits.
Her callisters were popping.
by Rutgers Univ April 13, 2005
 
2.
a blister under a callus
Why does my callus hurt so much? And why is it SQUISHY?!" "It's because you ran too much during manhunt last night... You got a blister under your callus now. It's called a callister, get with the program man!
by VotC December 19, 2010