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1.
This is a street in Los Angeles. But more importantly, cahuenga is synonymous for wang, sausage, shlong, cock, etc. A further constraint on the word, it is only used when describing a particularly large member.
A girl describes a hot night she spent with some guy, as she spills the juicy details she remarks, with a HUGE grin on her face, "yeah it was amazing, he had the hardest cahuenga and he knows how to work it..."
by Shortney April 18, 2006
 
2.
on Cahuenga
Girl #1: Did you see her all over that gay boy last night?

Girl #2: I'm afraid that I didn't. How did she pull that off?

Girl #1: Well let me tell you. Both of those bitches were on Cahuenga!
by SamWell92 July 10, 2010