look up any word, like dog in the bathtub:
 
2.
meant as a compliment. Buff muffin means you are someone that is cool and or sexy.
Hey your one buff muffin.(friend)
did you see that chick? She was such a buff muffin.(about attractive girl)
by Seeaann September 15, 2007
 
1.
female not wearing any panties under her pants
"Hey - I heard that Jane is going buffmuffin today !"
by Marty20525 July 25, 2007