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Blackup is a verb used as an insult to suburban white guys who need to grow a pair of balls and become more like their African American counterparts.
Jamal: Goddamit you casper lookalike, go on and talk to that girl...

Jeff (Caspter lookalike): No you've got it easy Jamal, you're STACKED where it counts and girls make me nervous.

Jamal: Blow it out your ass and blackup Jeff.
by 03UTREX July 01, 2009
Being stoned/lean past the point of no return...
I got well blackup off that draw last night...
by Law July 10, 2004
to make something good
im'a blackup dis party aaaiiiight!!
by Emanuel November 25, 2003