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1.
1. The most embarrassing way to end a phone conversation. Ever. Pioneered by nerdfighter John Green.

2. An expression of hope for another's welfare.
"And then, when it came time for the phone call to end, they were like, 'All right, well, take care, talk to you soon,' and I said 'Best wishes!' Best wishes?!"
by valerie2776 June 12, 2008
61 8
 
2.
Money sent or given to hookers by insecure men as payment for future sex

Honey, I won't be in New York until March 29th, so I am sending you 300 Best Wishes. So remember, I will be in NY from March 29th to April 6. Make time for me! Love ya'!
by Nancy Drew March 15, 2008
5 23