A disease, possibly terminal resulting from being a complete asshole.
His girlfriend dumped him because he has a bad case of assholitis. It might be terminal.
by Jeanine Albert September 28, 2007
Emanating an aura of aggressiveness and disdain towards others. It occurs in people from all ethnic groups; males are affected about three to four times more often than females unless provoked. Common side effect are the use of the word "stupid!" and attraction to physical violence and alcoholic beverages.
"Oh wow, I think I'm catching assholitis from you!!"
by xicana xingona May 31, 2007
The condition of a stupid or irritating person who has the behavior of being thoroughly contemptible and detestable.
He has a bad case of assholitis.
by Sheryl P. April 05, 2006
An occasional,sometimes chronic sickness caused by an excessive daily overabundance of contact with assholes. Usually in the workplace,but can come from many sources including traffic and local surroundings.
I seem to have come down with a touch of assholitis today.
by JoeNJ2 January 10, 2012