Up in someone's business, getting on someone's case, harping on someone, aggressively invasive or pursuant. Can be used to mean a woman whose aggressively pursuing a man. Can also be said all over my balls or just on my balls, or in terms of get off my balls or get off my back
My landlord was all up on my balls for the rent this month, dude needs to chill out

Your girl was all over your balls last night at that party

Man, why you all up on my balls, I already said sorry

Dude, get off my balls about it
by ptree March 25, 2008

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