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1.
A term used to express one's extreme discomfort of something or someone.

The term originates from being pissed off at someone that it you want to take out your frustration at someone.

One would feel extremely frustrated if a person who has an STD were to have anal sex with the person who is frustrated (especially if he is a guy).
Brian: "Dude dude dude let's listen to Justin Bieber."

Stephen: "Dude dude dude you make my ass burn."
by Raiky January 19, 2011
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