The stupidest thing to come about EVER. It stands for "You Only Live Once." It is very popular on Twitter, and when people use it on said website, you can expect a tweet saying they will do something stupid.
I'm going to go jump off of this 4th floor balcony! #YOLO

I'm going to punch a person with anger management problems! #YOLO

I'm going to do something else really stupid that will possibly injure or kill me! #YOLO

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You Only Live Once. Made popular by the artist Drake, and now unoriginal boring people are ripping it off him. Actually, Drake wasn't even the one that started the phrase. The deathcore band "Suicide Silence" made a song called "You Only Live Once" almost a year before Drake, and made a music video for it almost 6 months before Drake made the song. Since deathcore isn't such a popular genre among most people, it didn't become such an annoying assfuck untill Drake used it.
YOU ONLY LIVE ONCE, SO JUST GO FUCKING NUTS!! -headbangs-

**8-10 months later**

You only live once: that's the motto, nigga YOLO

**days later on facebook**
Newsfeeds
Useless fag 1: YOLO!
Useless fag 2: YOLO - You only live once! :)
Useless fag 3 You only live once! Hell yeah, YOLO!
etc...
by Shezz June 15, 2012

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A term that means: You Only Live Once. Is excessively used by scrubby kids who don't learn anything.
Angela: How are you, Mike?
Mike: YOLO!
via giphy
by GeneEight October 19, 2016

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you only live once
i yelled yolo as i jumped from the cliff
by gold robo cop November 04, 2015

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a term meaning "you only live once". Often used by instagrammers, persons imitating black males, and people trying to be hipsters (often failing because they conform to wearing fake glasses and growing mustaches)
i look so hot in this selfie. #YOLO
by mew ♥ mew August 27, 2014

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You only live once..... Pretty much Carpe Diem for fucknuts, dipshits, twat waffles, and other dregs of society
I had to kick the shit out of my neighbor after i caught him dropping a deuce in my yard yelling YOLO!
by DeezNutz79 July 23, 2013

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A sorry ass excuse for unscrupulous and unintelligible adolescents to initiate illogical and blatantly immoral actions. Widely used in 2012, it has been widely popularized by prepubescent girls and gayass teenage males to pose a rap-music cliche when they most likely don't even know who the fuck tuPac is. All YOLOers shall be executed in remote deathcamps for crudely insulting the English language, hence these filthy vile creatures are NOT human and therefore deserve little to no human rights. Yolo is jusy an overatted lyric published by Drake, a shitty cocksucking douchebag of a rapper, and is nothing more than the dumbass simple-english version of "CARPE DIEM" or"HUZZAH".
Dumbass YOLO ignoramus douche: "Yo, sup coz. I just got wasted last night and I fucked a bitch while she was asleep.
Normal Person: "Dude, you know the cops are after you for rape"

Dumbass YOLO ignoramus douche: "fuck it, YOLO!"

Scenario 2:

Yolo kid: Hey, I just robbed a bank, now I'm in prison for 30 years.
Me: You're a moron
YK: hey, YOLO
(I pick up my gun and shoot the YOLO kid in the face, he falls to the ground and dies.)
by huzzahzolzy May 16, 2013

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