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A version of YOLO applicable to high school students: You're Only in High School Once.
"Hey bro, should I ask her to prom?"

"YOHSO"
YOHSO by alejlsjdkf;gjirj November 4, 2012
Related Words
yohio Yoholler Yoshio yohi yohimbe yohomo yolio yoshioka Yoxious Yohao

Yohohohoho 

The shrill, strange, contagious sound that Brook from the anime "One Piece" makes when he laughs.
Brook (English Translation): "It has been over a few decades since I have eaten anything decent. It became so painful that the back of my stomach and my back were almost indistinguishable. That was the kind of life I lived for so many years. Then again, I am a skeleton so I don't have a stomach or back. Yohohohohohohohoho... SKULL JOKE!"
Yohohohoho by Holidaykay August 7, 2010
The Sexiest Guy at MIT. He s so hot, that when you look at him he burns your clothes of.
Girl 1 "What happen to you, you go out in the sun to much?"
Girl 2 "Na, I saw Yoshio !!!!"
Yoshio by 2pacforlife April 30, 2009

yoshiology 

The study of yoshis
Professor Magikarp's yoshiology studies are allowing us to learn more about the yoshis.
yoshiology by dratinimew August 23, 2012
A laugh made known by The Gentleman Skeleton,Brook.
Yohoho,girl.Would you let me see your panties?
Yohoho by 7tyseven October 30, 2007
Yoholler is simply holler except cooler. Derived by an anonymous "Maverick" at Hickory High School, yoholler has spreaded amongst the masses, ranging from 7th graders to working moms. Yoholler and its creator is officially a pop culture icon.
" Im gonna yoholler at some cheetos. You want some?"
In a more profane sense:
"I yohollered at your moms ***** last night ;-)"
Yoholler by Anonymous May 13, 2005