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Abbreviation of the slogan "XO Til' We Overdose".

X stands for the drug ecstasy, O for oxycodone, and secondarily it refers to OVOXO, which is a Canadian group consisting of Drake and The Weeknd.
Guy: "She be humpin' my pocket, XOTWOD while reaching her socket."

XO we'll be everything you need, just believe.
by Quinz May 24, 2013