Top Definition
The effect placed on a person during certain circumstances. May result in falling asleep in school, hysteria, or loss of self control. Usually characterized by all resulting from origin of a Wiley. AKA TWE.
Kennedy: "Look at Alexa over there!"
Alexa: "Are we going out for lunch? I would love to take my clothes off for you!"
Luke: "I know she is experiencing Tywiley Effect!"
by silentcomic September 29, 2011
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