When a number of things are irritating or causing you problems at once. The reference comes from describing a porn scene where a girl took double anal from a group of guys. Someone said, "She was having a Tylenol Weekend."
Bob can't find his keys, wallet, and he is running late for work - he must be having a Tylenol Weekend.
by Doc Irysch July 31, 2009

Free Daily Email

Type your email address below to get our free Urban Word of the Day every morning!

Emails are sent from daily@urbandictionary.com. We'll never spam you.

×