Top Definition
The effect produced by the climax of one's overly excited enjoyment, usually through the use of illegal substances.
Dude 1: What the fuck is that guy doing??

Dude 2: If your talking about the guy butt fucking that fire hydrant, he's twizzin'. He just railed 5 lines of coke.
by MyRealNameIsBLUMPKIN June 16, 2010
1 more definition
Twizzin' is like your daily swag and just being a "G". Also, just chillaxin. It shows that you got swag and you a real OG.
Mayne, we got choppaz, whips, and da ladies. We be Twizzin'
by Twizzy_Mike April 13, 2010

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