Top Definition
n. slang 1. A playful term used to describe a small framed female who often does not think before acting, but instead, and most often, acts and reacts on pure impulse without rhyme or reason.
(as she walks directly into a bedroom wall that has been there for years,) "Robin... That wall has been there for years. Why did you just walk into it? You're such a twerpy mouse."
by TwerpyMouseRobin March 10, 2009
7 Words related to Twerpy Mouse

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