Top Definition
1.)A person who addicted to drinking (alcohol) and enjoying uppers at the same time...Most of the time with devastating results.

2.)A drunken speed-freak
Person 1: Is Mary...drunk AND high right now.
Person 2: Yeeees, bitch! you know that bitch is a Tweekaholic
#druggy #tweaker #messy #addict #addiction #crazy
by MrHavok October 20, 2012
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