Top Definition
When a trucker guy or girl goes crazy from being in a truck for long periods of time, having to eat shitty food, and not knowing where the hell he/she is.
After only two days in the truck, Bob the trucker developd a severe case of trucker insanity; the truck smelled terrible because of all the greasy food he dropped, the seat was extremely uncomfortable, and he was in the middle of some random state with extremely cold temperatures without a jacket.
by arlingojo December 25, 2011

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