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1.
The most talented and sexiest man ever. He has had very succesful movies and show. He is in That 70's show, Win a Date with Tad Hamilton, Traffic, P.s., Mona Lisa Smile, In good Company, and Oceans 11 & 12. His real name is Christopher, but he changed it to Topher because he hated people calling him Chris.
I want to have my way with Topher Grace.
by Devon King March 19, 2005
 
2.
An actor who is more convincing as a bed-wetter than an action hero. Also see pansy wuss sissy.
Justin Long is such a Topher Grace.
by Panda Amry September 10, 2009