Top Definition
A syndrome that engulfs Big Brother houseguests in the event that fellow houseguest Jessie Godderz gets evicted.

Symptoms of the Jessie Effect include but are not limited to: referring to Catholics as "Judas," arguing ridiculously, becoming very verbal for no reason whatsoever, throwing your microphone pack into the Hot Tub, threatening to shit on everything, general disregard for the welfare of the house, general disregard for Big Brother rules
Chima "Chimarosa" Simone , Lydia Tavera, and Natalie Martinez from Big Brother XI all suffered The Jessie Effect.

As did Libra Thompson, Jerry MacDonald, and April Dowling from Big Brother X.
by imthedomin8er July 30, 2010
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