Top Definition
A derogatory slang word derived from the movie "Splice". Used to describe an ugly individual with odd androgynous facial features. In the movie The splice creature was both woman and man. A creature with a face only a mother could love.
Dude check out the Splice Baby behind you

NUH UH WHERE?! Oh wow man eww that's gotta suck to look like that.

For real.
by aharharhardyhar November 16, 2010
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