A euphemism for diarrhea, aka the hershey squirts. The term is a play on Southern Comfort, an alcoholic drink and the modified version refers to discomfort in the southern region of the body, the bowels.
Mike - "Are you feeling any better, Elizabeth?"
Elizabeth - "No, I've still got some Southern Discomfort..."
by LizardBreath16 August 10, 2009

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