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A small high school in in the southern part of Effingham County in South Georgia. Known for their annoying herd of Mustangs and their failtastic football team. This is where all the hicks, rednecks, and inbreds go to school.
A: "Did that guy just kiss his sister?!"
B: "Yeah, they go to South Effingham."
A: "Ohhhh....that explains it."
by lolsmileyface2444 July 17, 2011
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