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1.
The act of uppercutting someone, while yelling shut the fuck up
person 1:haha i heard during school today, john gave donnie a shut the fuck uppercut

person 2: OW! that must have hurt...
by Anthbroo December 29, 2012
 
2.
a prolonged version of stfu, usually used to express further anger.
"oh my god! so i heard jenny talking about cindy saying she was going out with brad and sarah was cheating on him with ricky and-"
"SHUT THE FUCK UPPERCUT!"
by dagreatdane4 July 01, 2009